Cart
sales@molnova.com
Home - Products - Angiogenesis - PDE - PF 05180999

PF 05180999

CAS No. 1394033-54-5

PF 05180999 ( PF-05180999;PF05180999;PF 5180999 )

Catalog No. M11643 CAS No. 1394033-54-5

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 284 Get Quote
50MG 480 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF 05180999
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
  • Description
    PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM; displays >1,000-fold selectivity over PDE10; shows potential for treatment of schizophrenia.Schizophrenia Phase 1 Discontinued
  • Synonyms
    PF-05180999;PF05180999;PF 5180999
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1394033-54-5
  • Formula Weight
    414.40
  • Molecular Formula
    C19H17F3N8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 120.66 mM
  • SMILES
    FC(C1=CN=C(C2=C(C3=C4C(N5CCC5)=NC=NN4C(C)=N3)C=NN2C)C=C1)(F)F
  • Chemical Name
    4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.
2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BAY 2666605

    BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.

  • Udenafil

    A potent and selective phosphodiesterase 5 (PDE5) inhibitor for treat erectile dysfunction.

  • Ginkgolide J

    Ginkgolide J has neuroprotective activity it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.

Sign In Join Free