PF 05180999 ( PF-05180999;PF05180999;PF 5180999 )

Catalog No. M11643 CAS No. 1394033-54-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PF 05180999
Note

Research use only, not for human use.
Brief Description

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
Description

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM; displays >1,000-fold selectivity over PDE10; shows potential for treatment of schizophrenia.Schizophrenia Phase 1 Discontinued
Synonyms

PF-05180999;PF05180999;PF 5180999
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Neurological Disease
Indication

Schizophrenia

CAS Number

1394033-54-5
Formula Weight

414.40
Molecular Formula

C19H17F3N8
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 120.66 mM
SMILES

FC(C1=CN=C(C2=C(C3=C4C(N5CCC5)=NC=NN4C(C)=N3)C=NN2C)C=C1)(F)F
Chemical Name

4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.
2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.

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